A new dicoumarin and anticoagulant activity from Viola yedoensis Makino

  • Fitoterapia. 2009 Jul;80(5):283-5. doi: 10.1016/j.fitote.2009.03.005.
Hai Yan Zhou  1 ,  Jun Li Hong ,  Pan Shu ,  Yue Juan Ni ,  Min Jian Qin
Affiliations
  • 1. Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing, China. [email protected]
PMID: 19306914 DOI: 10.1016/j.fitote.2009.03.005
Abstract

A new dicoumarin, named as dimeresculetin (1), together with another dicoumarin, euphorbetin (2) and esculetin (3) were isolated from the ethyl acetate extract of the dried whole Plants of Viola yedoensis Makino. The structure of 1 was elucidated as 7-hydroxy-6-[(6,7-dihydroxy-2-oxo-2H-1-benzopyran-5-yl)oxy]-2H-1-benzopyran-2-one on the basis of extensive NMR, as well as the Other spectral analysis. Compounds 1-3 exhibited anticoagulant activities with respect to activated partial thromboplastin time (APTT), prothrombin time (PT) and Thrombin time (TT).

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