Cathepsin K: a therapeutic target for bone diseases
- Biochem Biophys Res Commun. 2009 Mar 20;380(4):721-3. doi: 10.1016/j.bbrc.2009.01.139.
Affiliations
- 1. College of Chemical Engineering, Northeast Dianli University, Jilin, PR China.
PMID: 19338743
DOI: 10.1016/j.bbrc.2009.01.139
Abstract
Cathepsin K is a member of the papain family of cysteine proteases and is highly expressed in osteoclasts that mediate bone resorption. In this review, some of the known features of Cathepsin K such as structure, function in bone resorption, gene regulation and its roles in physiological or pathophysiological processes are highlighted.