Two new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities

  • J Asian Nat Prod Res. 2009;11(5):451-6. doi: 10.1080/10286020902845652.
Sheng-Jun Dai  1 ,  Wei-Bing Peng ,  Li Shen ,  De-Wu Zhang ,  Yan Ren
Affiliations
  • 1. School of Pharmaceutical Science, Yantai University, Yantai, China. [email protected]
PMID: 19504388 DOI: 10.1080/10286020902845652
Abstract

Two new neo-clerodane diterpenoid Alkaloids, scutebarbatine O (1) and 6-O-nicotinoylscutebarbatine G (2), were isolated from the whole plant of Scutellaria barbata. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1 and 2 showed cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC(50) values in the range of 2.1-5.7 microM.

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