Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines

  • Bioorg Med Chem Lett. 2009 Nov 15;19(22):6368-72. doi: 10.1016/j.bmcl.2009.09.066.
Christopher S Burgey  1 ,  Craig M Potteiger ,  James Z Deng ,  Scott D Mosser ,  Christopher A Salvatore ,  Sean Yu ,  Shane Roller ,  Stefanie A Kane ,  Joseph P Vacca ,  Theresa M Williams
Affiliations
  • 1. Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. [email protected]
PMID: 19818613 DOI: 10.1016/j.bmcl.2009.09.066
Abstract

Several novel spiropiperidine-based CGRP Receptor antagonists have been developed that maintain good potency and have reduced potential for metabolism.