A new cytotoxic flavonoid from the fruit of Sinopodophyllum hexandrum

  • Fitoterapia. 2010 Jul;81(5):367-70. doi: 10.1016/j.fitote.2009.11.003.
Yue Kong  1 ,  Jun-Jun Xiao ,  Shu-Cong Meng ,  Xiao-Min Dong ,  Yue-Wei Ge ,  Ru-Feng Wang ,  Ming-Ying Shang ,  Shao-Qing Cai
Affiliations
  • 1. Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China.
PMID: 19909799 DOI: 10.1016/j.fitote.2009.11.003
Abstract

Constituents of the fruit of Sinopodophyllum hexandrum (Royle) Ying (Sinopodophylli Fructus) were investigated. A new flavonoid, 8,2'-diprenylquercetin 3-methyl ether along with 9 known compounds were isolated and identified. Among them, the new compound 8,2'-diprenylquercetin 3-methyl ether exhibited cytotoxic activities against MDA-231 and T47D breast Cancer cell lines, quercetin, kaempferol and rutin were isolated from Sinopodophylli Fructus for the first time.

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