Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates

  • Bioorg Med Chem Lett. 2010 Jun 1;20(11):3310-3. doi: 10.1016/j.bmcl.2010.04.037.
Ahmed Kamal  1 ,  E Vijaya Bharathi ,  M Janaki Ramaiah ,  J Surendranadha Reddy ,  D Dastagiri ,  A Viswanath ,  Farheen Sultana ,  S N C V L Pushpavalli ,  Manika Pal-Bhadra ,  Aarti Juvekar ,  Subrata Sen ,  Surekha Zingde
Affiliations
  • 1. Chemical Biology Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India. [email protected]
PMID: 20444601 DOI: 10.1016/j.bmcl.2010.04.037
Abstract

A series of novel anthranilamide linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates were prepared and evaluated for their Anticancer activity. The effects of three promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These promising compounds showed the characteristic features of Apoptosis like enhancement in the levels of p53 and activation of Caspase-3.