ZAP-70: an essential kinase in T-cell signaling

  • Cold Spring Harb Perspect Biol. 2010 May;2(5):a002279. doi: 10.1101/cshperspect.a002279.
Haopeng Wang  1 ,  Theresa A Kadlecek ,  Byron B Au-Yeung ,  Hanna E Sjölin Goodfellow ,  Lih-Yun Hsu ,  Tanya S Freedman ,  Arthur Weiss
Affiliations
  • 1. Howard Hughes Medical Institute, Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA.
PMID: 20452964 DOI: 10.1101/cshperspect.a002279
Abstract

ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor.