Synthesis and antiviral activities of synthetic glutarimide derivatives

  • Chem Pharm Bull (Tokyo). 2010 Nov;58(11):1436-41. doi: 10.1248/cpb.58.1436.
Xing-yue Ji  1 ,  Zhao-jin Zhong ,  Si-tu Xue ,  Shuai Meng ,  Wei-ying He ,  Rong-mei Gao ,  Yu-huan Li ,  Zhuo-rong Li
Affiliations
  • 1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People’s Republic of China.
PMID: 21048333 DOI: 10.1248/cpb.58.1436
Abstract

A series of novel glutarimide compounds were synthesized and their Antiviral activities were evaluated. The compounds displaying the strongest Antiviral activities included 5, 6f, 7e and 9 against coxsackievirus B3 (COX B3), 10 and 6f against Influenza Virus A (influenza A) and 7a against herpes simplex virus 2 (HSV-2). However, most of the synthetic glutarimides showed comparatively much weaker activity against influenza A, COX B3 and HSV-2 than the natural glutarimide compounds tested. Based on the results, it seemed likely that a conjugated system at the β-substituted moiety provides stronger Antiviral activity.

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