A helix-loop-helix protein related to the immunoglobulin E box-binding proteins

  • Mol Cell Biol. 1990 Aug;10(8):4384-8. doi: 10.1128/mcb.10.8.4384-4388.1990.
C S Carr  1 ,  P A Sharp
Affiliations
  • 1. Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
PMID: 2115126 DOI: 10.1128/mcb.10.8.4384-4388.1990
Abstract

A human cDNA encoding a novel protein in the helix-loop-helix family has been isolated by screening a bacteriophage expression library with a probe containing the binding site for major late transcription factor. The protein encoded by this cDNA, TFEB, probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer.