Efficiency of lyticase (bacterial enzyme) in experimental candidal vaginitis in mice

  • Bull Exp Biol Med. 2010 Nov;149(6):727-30. doi: 10.1007/s10517-010-1037-6.
N P Sachivkina  1 ,  E G Kravtsov ,  E A Wasileva ,  I V Anokchina ,  M V Dalin
Affiliations
  • 1. Department of Microbiology, Russian University of Peoples' Friendship, Moscow, Russia.
PMID: 21165431 DOI: 10.1007/s10517-010-1037-6
Abstract

Lyticase (a Bacterial enzyme) was tested as a new antimycotic drug. Of all objects studied, Cellulomonas cellulans AC-870 strain proved to be most productive for this enzyme. A technology for lyticase isolation and purification was proposed. An experimental model of recurrent vaginal candidiasis was created. The model includes combined Antibiotic and estradiol therapy. Antimycotic effect of lyticase on the model of recurrent vaginal candidiasis in mice was demonstrated.

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