Applications of X-ray scattering in pharmaceutical science

  • Int J Pharm. 2011 Sep 30;417(1-2):101-11. doi: 10.1016/j.ijpharm.2011.01.022.
Yao-Da Dong  1 ,  Ben J Boyd
Affiliations
  • 1. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.
PMID: 21256941 DOI: 10.1016/j.ijpharm.2011.01.022
Abstract

The use of X-ray scattering techniques in pharmaceutical science is increasing, in part through increased collaborations with the Materials science community, and through increased availability of instrumentation, particularly synchrotron sources. The ability to understand not only the biopharmaceutical outcome, but also arguably, more importantly, the structural aspects of drugs and drug delivery systems, is essential to progressing pharmaceutical science; this review serves as an introduction to the major techniques and the wide range of areas in which X-ray scattering may be applied in understanding and controlling structure in pharmaceutical systems.