Cytotoxic clerodane diterpenes from Casearia rupestris

  • J Nat Prod. 2011 Apr 25;74(4):776-81. doi: 10.1021/np100840w.
Gerardo M Vieira-Júnior  1 ,  Luiz A Dutra ,  Paulo M P Ferreira ,  Manoel O de Moraes ,  Letícia V Costa Lotufo ,  Cláudia do Ó Pessoa ,  Roseli Buzanelli Torres ,  Nivaldo Boralle ,  Vanderlan da S Bolzani ,  Alberto J Cavalheiro
Affiliations
  • 1. Institute of Chemistry, Nucley of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE), São Paulo State University, UNESP, C.P. 14801-970, Araraquara, SP, Brazil.
PMID: 21381705 DOI: 10.1021/np100840w
Abstract

Four new clerodane diterpenes, casearupestrins A-D (1-4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6). All compounds were evaluated for cytotoxicity against a small panel of human Cancer cell lines. Casearupestrin A (1) exhibited the most potent activity against MDA/MB-435 (human melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug doxorubicin.