Total synthesis of a CD-ring: side-chain building block for preparing 17-epi-calcitriol derivatives from the Hajos-Parrish dione

  • J Org Chem. 2011 Aug 19;76(16):6906-11. doi: 10.1021/jo201083w.
Karol Michalak  1 ,  Jerzy Wicha
Affiliations
  • 1. Institute of Organic Chemistry, Polish Academy of Sciences, ul. Kasprzaka 44/52, 01-224 Warsaw, Poland.
PMID: 21728301 DOI: 10.1021/jo201083w
Abstract

An efficient synthesis of the key building block for 17-epi-calctriol from the Hajos-Parrish dione involving a sequence of diastereoselective transformation of the azulene core and the side-chain construction is presented.

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