Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents

  • Bioorg Med Chem Lett. 2011 Nov 15;21(22):6788-92. doi: 10.1016/j.bmcl.2011.09.034.
Hong-wang Zhang  1 ,  Longhu Zhou ,  Steven J Coats ,  Tamara R McBrayer ,  Phillip M Tharnish ,  Lavanya Bondada ,  Mervi Detorio ,  Sarah A Amichai ,  Melissa D Johns ,  Tony Whitaker ,  Raymond F Schinazi
Affiliations
  • 1. Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
PMID: 21983447 DOI: 10.1016/j.bmcl.2011.09.034
Abstract

Based on the anti-hepatitis C activity of 2'-C-methyl-adenosine and 2'-C-methyl-guanosine, a series of new modified purine 2'-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2'-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells.