A Simple Route for Synthesis of 4-Phospho-D-Erythronate

  • Tetrahedron Lett. 2011 Apr 20;52(16):1913-1915. doi: 10.1016/j.tetlet.2011.02.045.
Yehor Novikov  1 ,  Shelley D Copley ,  Bruce E Eaton
Affiliations
  • 1. Department of Molecular, Cellular and Developmental Biology and Cooperative Institute for Research in Environmental Sciences, University of Colorado at Boulder, Boulder, CO 80309.
PMID: 22200980 DOI: 10.1016/j.tetlet.2011.02.045
Abstract

4-Phospho-D-erythronate is an intermediate in synthesis of pyridoxal 5'-phosphate in some bacteria and an inhibitor of ribose 5-phosphate isomerase. Previous synthetic schemes for the preparation of 4-phospho-D-erythronate required expensive precursors and typically gave low yields. We report a straightforward synthesis of 4-phospho-D-erythronate from the inexpensive precursor D-erythronolactone in 5 steps with a preparatively useful yield of 22%.

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