Secondary metabolites from an algicolous Aspergillus versicolor strain

  • Mar Drugs. 2012 Jan;10(1):131-139. doi: 10.3390/md10010131.
Feng-Ping Miao  1 ,  Xiao-Dong Li  1 ,  Xiang-Hong Liu  1 ,  Robert H Cichewicz  2 ,  Nai-Yun Ji  1
Affiliations
  • 1. Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
  • 2. Natural Products Discovery Group, Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.
PMID: 22363226 DOI: 10.3390/md10010131
Abstract

Two new compounds, asperversin A (1) and 9ξ-O-2(2,3-dimethylbut-3-enyl)brevianamide Q (2), and nine known compounds, brevianamide K (3), brevianamide M (4), aversin (5), 6,8-di-O-methylnidurufin (6), 6,8-di-O-methylaverufin (7), 6-O-methylaverufin (8), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (9), ergosta-7,22-diene-3β,5α,6β-triol (10), and 6β-methoxyergosta-7,22-diene-3β,5α-diol (11), were obtained from the culture of Aspergillus versicolor, an endophytic fungus isolated from the marine brown alga Sargassum thunbergii. The structures of these compounds were established by spectroscopic techniques. Compounds 4, 7 and 8 exhibited Antibacterial activities against Escherichia coli and Staphyloccocus aureus, and 7 also showed lethality against brine shrimp (Artemia salina) with an LC₅₀ value of 0.5 μg/mL.

Keywords
9ξ-O-2(2,3-dimethylbut-3-enyl)brevianamide Q; Aspergillus versicolor; Sargassum thunbergii; asperversin A.
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