Recent advances in the study of enzyme promiscuity in the tautomerase superfamily

  • Chembiochem. 2013 May 27;14(8):917-26. doi: 10.1002/cbic.201300098.
Bert-Jan Baas  1 ,  Ellen Zandvoort ,  Edzard M Geertsema ,  Gerrit J Poelarends
Affiliations
  • 1. Department of Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
PMID: 23649962 DOI: 10.1002/cbic.201300098
Abstract

Catalytic promiscuity and evolution: Many Enzymes exhibit catalytic promiscuity--the ability to catalyze reactions Other than their biologically relevant one. These reactions can serve as starting points for both natural and laboratory evolution of new enzymatic functions. Recent advances in the study of enzyme promiscuity in the tautomerase superfamily are discussed.

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