Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum

  • Phytochemistry. 2013 Dec:96:360-9. doi: 10.1016/j.phytochem.2013.10.005.
Yuan-Yuan Cheng  1 ,  Huan Chen ,  Hong-Ping He ,  Yu Zhang ,  Shi-Fei Li ,  Gui-Hua Tang ,  Ling-Li Guo ,  Wei Yang ,  Feng Zhu ,  Yong-Tang Zheng ,  Shun-Lin Li ,  Xiao-Jiang Hao
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China; Graduate University of Chinese Academy of Sciences, Beijing 100039, People's Republic of China.
PMID: 24210372 DOI: 10.1016/j.phytochem.2013.10.005
Abstract

Sixteen daphnane Diterpenoids, trigothysoids A-P, along with 15 known ones, were isolated from the methanol extract of the twigs and leaves of Trigonostemon thyrsoideum. Their structures were established by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry. The anti-HIV-1 activity of the compounds was also evaluated in vitro, and five compounds demonstrated potent anti-HIV-1 activity, with EC50 values of 0.015-0.001 nM and TI values of 1618-17,619.

Keywords
Anti-HIV-1; Daphnane diterpenoids; Euphorbiaceae; Trigonostemon thyrsoideum; Trigothysoids A−P.
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