Copper-mediated radical trifluoromethylation of unsaturated potassium organotrifluoroborates

  • J Org Chem. 2013 Dec 20;78(24):12837-43. doi: 10.1021/jo4023233.
Marc Presset  1 ,  Daniel Oehlrich ,  Frederik Rombouts ,  Gary A Molander
Affiliations
  • 1. Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , Philadelphia, Pennsylvania 19104-6323, United States.
PMID: 24251623 DOI: 10.1021/jo4023233
Abstract

Copper-mediated trifluoromethylation of unsaturated organotrifluoroborates with the Langlois reagent (NaSO2CF3) and TBHP allows the introduction of trifluoromethyl groups into a variety of organic substructures. The reactions are easy to set up, the conditions are mild and general, and the process provides access to trifluoromethylated alkynes, alkenes, arenes, and heteroarenes in fair to good yields.

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