5alpha,8alpha-epidioxysterols from a Formosan sponge, Axinyssa sp

  • Nat Prod Commun. 2013 Nov;8(11):1535-6.
Tzu-Rong Su  1 ,  Kai-Ju Liang  2 ,  Michael Y Chiang  3 ,  Mei-Chin Lu  2 ,  Yu-Jen Wue  4 ,  Jui-Hsin Su  2
Affiliations
  • 1. Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan.
  • 2. National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
  • 3. Department of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
  • 4. Department ofBeauty Science, Meiho University, Pingtung 912, Taiwan.
PMID: 24427934
Abstract

One new 5alpha,8alpha-epidioxysterol, 3-acetylaxinysterol (1), along with one known sterol, axinysterol (2), were isolated from a Formosan Sponge, Axinyssa sp.. The structures of the compounds were determined by spectroscopic methods and the absolute configuration of 2 was further confirmed by single-crystal X-ray diffraction analysis for the first time. Compound 2 exhibited significant cytotoxicity against K562 and Molt 4 Cancer cell lines.

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