Enantiodifferentiation through frequency-selective pure-shift (1)H nuclear magnetic resonance spectroscopy

  • Chemphyschem. 2014 Apr 4;15(5):854-7. doi: 10.1002/cphc.201301130.
Laura Castañar  1 ,  Míriam Pérez-Trujillo ,  Pau Nolis ,  Eva Monteagudo ,  Albert Virgili ,  Teodor Parella
Affiliations
  • 1. Servei de Ressonància Magnètica Nuclear and Departament de Química, Universitat Autònoma de Barcelona, 08193 Bellaterra (Spain), Tel: (+34) 935812291.
PMID: 24677772 DOI: 10.1002/cphc.201301130
Abstract

A frequency-selective 1D (1) H nuclear magnetic resonance (NMR) experiment for the fast and sensitive determination of chemical-shift differences between overlapped resonances is proposed. The resulting fully homodecoupled (1) H NMR resonances appear as resolved 1D singlets without their typical J(HH) coupling constant multiplet structures. The high signal dispersion that is achieved is then exploited in enantiodiscrimination studies by using chiral solvating agents.

Keywords
chemical shift; enantioselectivity; homodecoupling; nmr spectroscopy; single pulsed-field-gradient echo.
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