A benzoic acid derivative and flavokawains from Piper species as schistosomiasis vector controls

  • Molecules. 2014 Apr 23;19(4):5205-18. doi: 10.3390/molecules19045205.
Ludmila N Rapado  1 ,  Giovana C Freitas  2 ,  Adriano Polpo  3 ,  Maritza Rojas-Cardozo  4 ,  Javier V Rincón  5 ,  Marcus T Scotti  6 ,  Massuo J Kato  7 ,  Eliana Nakano  8 ,  Lydia F Yamaguchi  9
Affiliations
  • 1. Laboratório de Parasitologia, Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, SP, CEP 05503-900, Brazil. [email protected].
  • 2. Research Support Center in Diversity of Natural Products, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, sala 1124, São Paulo, SP, CEP 05508-000, Brazil. [email protected].
  • 3. Departamento de Estatística, Centro de Ciências Exatas e de Tecnologia, Universidade Federal de São Carlos, Via Washington Luís, km 235, Sao Carlos, SP, Caixa-postal 676, CEP 13565-905, Brazil. [email protected].
  • 4. Department of Pharmacy, Faculty of Sciences, Universidad Nacional de Colombia, Kr 30 45-03, Bogotá, Colombia.
  • 5. Department of Pharmacy, Faculty of Sciences, Universidad Nacional de Colombia, Kr 30 45-03, Bogotá, Colombia. [email protected].
  • 6. Centro de Ciências Aplicadas e Educação, Universidade Federal da Paraíba, Campus IV, Rua da Mangueira, s/n, Rio Tinto, PB, CEP 5829-7000, Brazil. [email protected].
  • 7. Research Support Center in Diversity of Natural Products, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, sala 1124, São Paulo, SP, CEP 05508-000, Brazil. [email protected].
  • 8. Laboratório de Parasitologia, Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, SP, CEP 05503-900, Brazil. [email protected].
  • 9. Research Support Center in Diversity of Natural Products, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, sala 1124, São Paulo, SP, CEP 05508-000, Brazil.
PMID: 24762961 DOI: 10.3390/molecules19045205
Abstract

The search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A new benzoic acid derivative and three flavokawains from Piper diospyrifolium, P. cumanense and P. gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, "in silico" studies were performed using docking assays and Molecular Interaction Fields to evaluate the physical-chemical differences among the compounds in order to characterize the observed activities of the test compounds against Biomphalaria glabrata snails.

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