Seven new sesquiterpenoids from the fruits of Schisandra sphenanthera

  • Chem Biodivers. 2014 Jul;11(7):1053-68. doi: 10.1002/cbdv.201300259.
Yao-Ching Tsai  1 ,  Yuan-Bin Cheng ,  I-Wen Lo ,  Ho-Hsi Cheng ,  Ching-Jie Lin ,  Tsong-Long Hwang ,  Yuh-Chi Kuo ,  Shorong-Shii Liou ,  Yi-Zsau Huang ,  Yao-Haur Kuo ,  Ya-Ching Shen
Affiliations
  • 1. School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Rd. Sec. 1, Taipei 100, Taiwan (phone: +886-2-23123456, ext. 62226; fax: +886-2-23919098).
PMID: 25044591 DOI: 10.1002/cbdv.201300259
Abstract

Fractionation of the EtOH extract from the fruits of Schisandra sphenanthera resulted in the isolation of seven new sesquiterpenoids, 1-7, in addition to the known metabolites 8-23. Among them, schiscupatetralin A (1) possesses an unprecedented structure with a CC bond between cuparenol and tetralin. The isolated new compounds were evaluated for their anti-HSV-1 and anti-inflammatory activities. The results revealed that compound 4 exhibited anti-HSV-1 activity, while compound 6 showed a significant anti-inflammatory activity.

Keywords
Anti-HSV-1 activity; Anti-inflammatory activity; Schisandra sphenanthera; Sesquiterpenoids.
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