The first synthesis of the antiangiogenic homoisoflavanone, cremastranone

  • Org Biomol Chem. 2014 Oct 21;12(39):7673-7. doi: 10.1039/c4ob01604a.
Bit Lee  1 ,  Halesha D Basavarajappa ,  Rania S Sulaiman ,  Xiang Fei ,  Seung-Yong Seo ,  Timothy W Corson
Affiliations
  • 1. College of Pharmacy and Gachon Institute of Pharmaceutical Sciences, Gachon University, Incheon, South Korea. [email protected].
PMID: 25167470 DOI: 10.1039/c4ob01604a
Abstract

An antiangiogenic homoisoflavanone, cremastranone, was synthesized for the first time. This scalable synthesis, which includes selective demethylation, could be used to develop lead molecules to treat angiogenesis-induced eye diseases. Synthetic cremastranone inhibited the proliferation, migration and tube formation ability of human retinal microvascular endothelial cells, important steps in pathological angiogenesis.

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