Antiepileptic C21 steroids from the roots of Cynanchum otophyllum

  • J Asian Nat Prod Res. 2015;17(7):724-32. doi: 10.1080/10286020.2014.1001380.
Xiang Li  1 ,  Mi Zhang ,  Cheng Xiang ,  Bao-Cai Li ,  Peng Li
Affiliations
  • 1. a Faculty of Life Science and Technology, Kunming University of Science and Technology , Kunming 650500 , China.
PMID: 25579837 DOI: 10.1080/10286020.2014.1001380
Abstract

In order to discover more natural products possessing potentially antiepileptic activities, three C21 Steroids, including a new one, characterized as caudatin-3-O-β-D-cymaropyranosyl-(1 → 4)-β-D-cymaropyranosyl-(1 → 4)-β-D-cymaropyranoside (1), and two known analogs, otophylloside B (2) and caudatin-3-O-β-D-oleandropyranosyl-(1 → 4)-β-D-oleandropyranosyl-(1 → 4)-β-D-cymaropyranosyl-(1 → 4)-β-D-cymaropyranoside (3), were isolated from the chloroform extract of the roots of Cynanchum otophyllum and evaluated for their antiepileptic activities by pentylenetrazole (PTZ)-induced zebrafish larval locomotor assay. The results showed that all of them had marked activities of suppressing PTZ-induced seizure behaviors in larval zebrafish at the dose of 10 μg/ml.

Keywords
C21 steroid; Cynanchum otophyllum; antiepileptic effect; zebrafish.
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