Five new diarylheptanoids from the rhizomes of Curcuma kwangsiensis and their antiproliferative activity

  • Fitoterapia. 2015 Apr;102:67-73. doi: 10.1016/j.fitote.2015.02.004.
Shao-Dan Chen  1 ,  Jin-Tao Gao  2 ,  Jing-Gong Liu  2 ,  Bo Liu  2 ,  Rui-Zhi Zhao  2 ,  Chuan-Jian Lu  3
Affiliations
  • 1. The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China; Postdoctoral Programme, Guangzhou University of Chinese Medicine, Guangzhou 510000, China.
  • 2. The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China.
  • 3. The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China. Electronic address: [email protected].
PMID: 25704367 DOI: 10.1016/j.fitote.2015.02.004
Abstract

Five new diarylheptanoids (1-5), along with nine known ones (6-14), were isolated from the rhizomes of Curcuma kwangsiensis. Their structures were established on the basis of spectroscopic analyses. Compounds 1-3 were cyclic diarylheptanoids rarely discovered from C. kwangsiensis. Of all the isolated compounds, compound 4 showed moderate antiproliferative activity on HH and HaCaT cells.

Keywords
Antiproliferation; Curcuma kwangsiensis; Diarylheptanoids; HH cells; HaCaT cells.
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