Bisacremines A-D, Dimeric Acremines Produced by a Soil-Derived Acremonium persicinum Strain

  • J Nat Prod. 2015 Sep 25;78(9):2161-6. doi: 10.1021/np501037x.
Ping Wu  1 ,  Lei Yao  1 ,  Liangxiong Xu  1 ,  Jinghua Xue  1 ,  Xiaoyi Wei  1
Affiliations
  • 1. Key Laboratory of Plant Resources Conservation and Sustainable Utilization and Guangdong Provincial Key Laboratory of Digital Botanical Garden, South China Botanical Garden, Chinese Academy of Sciences , Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
PMID: 26295905 DOI: 10.1021/np501037x
Abstract

Four dimeric acremines, bisacremines A-D (1-4), with a novel carbon skeleton and a new monomer, acremine T (5), were obtained from cultures of the soil-derived fungus Acremonium persicinum SC0105. Their structures were characterized by analysis of spectroscopic data, ECD/TDDFT computations, and X-ray diffraction. Compounds 1 and 2 exhibited weak cytotoxicity against HeLa cells, and 2 also showed modest activity against A549 and HepG2 cells.