Sulfotanone, a new alkyl sulfonic acid derivative from Streptomyces sp. IFM 11694 with TRAIL resistance-overcoming activity

  • J Nat Med. 2016 Apr;70(2):266-70. doi: 10.1007/s11418-015-0951-3.
Mohamed S Abdelfattah  1  2 ,  Naoki Ishikawa  1 ,  Utpal K Karmakar  1 ,  Masami Ishibashi  3
Affiliations
  • 1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan.
  • 2. Chemistry Department, Faculty of Science, Helwan University, Cairo, 11795, Egypt.
  • 3. Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan. [email protected].
PMID: 26607379 DOI: 10.1007/s11418-015-0951-3
Abstract

One new alkyl sulfonic acid derivative, sulfotanone (1), and the known panosialin wA (2) were isolated from the methanolic extract of mycelium of Streptomyces sp. 11694. The structure of the new compound (1) was established by a combination of spectroscopic techniques, including HRESIMS, IR, 1D and 2D NMR measurements. Compound 1 (40 µM) in combination with TRAIL showed synergistic activity in sensitizing TRAIL-resistance in human gastric adenocarcinoma cell lines.

Keywords
Actinomycetes; Spectroscopy; Sulfonic acid; TRAIL.
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