Death Associated Protein Kinase 1 (DAPK1): A Regulator of Apoptosis and Autophagy

  • Front Mol Neurosci. 2016 Jun 23:9:46. doi: 10.3389/fnmol.2016.00046.
Pratibha Singh  1 ,  Palaniyandi Ravanan  1 ,  Priti Talwar  1
Affiliations
  • 1. Apoptosis and Cell Survival Research Laboratory, Department of Bio-Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT) University Vellore, Tamil Nadu, India.
PMID: 27445685 DOI: 10.3389/fnmol.2016.00046
Abstract

Death-Associated Protein Kinase 1 (DAPK1) belongs to a family of five serine/threonine (Ser/Thr) kinases that possess tumor suppressive function and also mediate a wide range of cellular processes, including Apoptosis and Autophagy. The loss and gain-of-function of DAPK1 is associated with various Cancer and neurodegenerative diseases respectively. In recent years, mechanistic studies have broadened our knowledge of the molecular mechanisms involved in DAPK1-mediated Autophagy/Apoptosis. In the present review, we have discussed the structural information and various cellular functions of DAPK1 in a comprehensive manner.

Keywords
apoptosis; autophagy; cancer; death-associated protein kinase 1; neurodegenerative disease.