Studies on new phosphate ester antifungal antibiotics phoslactomycins. II. Structure elucidation of phoslactomycins A to F

  • J Antibiot (Tokyo). 1989 Jul;42(7):1026-36. doi: 10.7164/antibiotics.42.1026.
S Fushimi  1 ,  K Furihata ,  H Seto
Affiliations
  • 1. Institute of Applied Microbiology, University of Tokyo, Japan.
PMID: 2753809 DOI: 10.7164/antibiotics.42.1026
Abstract

Phoslactomycins A to F are new antifungal Antibiotics produced by Streptomyces nigrescens SC-273. On the basis of physico-chemical properties and NMR studies, their structures have been determined as shown in Fig. 6. They are characterized by possessing alpha, beta-unsaturated delta-lactone, phosphate ester, conjugated diene and cyclohexane ring moieties. The structural difference between them is ascribed to a substituent bound to the cyclohexane ring.

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