A new synthesis and preliminary evaluation of some analogues of mecamylamine - a compound with anti-addiction properties

  • Org Biomol Chem. 2016 Nov 22;14(46):10787-10798. doi: 10.1039/c6ob01974a.
David Mangan  1 ,  Neasa McNabola  1 ,  Emily H Clark  2 ,  Isabel Bermudez  3 ,  Susan Wonnacott  2 ,  J Mike Southern  1
Affiliations
  • 1. Trinity Biomedical Sciences Institute, School of Chemistry, The University of Dublin, Trinity College, Dublin 2, Ireland. [email protected].
  • 2. Department of Biology & Biochemistry, University of Bath, Bath BA2 7AY, UK.
  • 3. School of Life Sciences, Oxford Brookes University, Oxford OX3 0BP, UK.
PMID: 27812593 DOI: 10.1039/c6ob01974a
Abstract

A new synthesis of mecamylamine - a known anti-hypertensive drug with anti-addictive properties is described. The new route allowed access to two novel analogues whose activity at two nicotinic acetylcholine receptor subtypes was assessed.

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