A streptothricin-like antibiotic mixture, A-269A (and A-269A')

  • J Antibiot (Tokyo). 1987 Dec;40(12):1698-706. doi: 10.7164/antibiotics.40.1698.
Y Kido  1 ,  T Furuie ,  K Suzuki ,  K Sakamoto ,  Y Yokoyama ,  M Uyeda ,  J Kinjyo ,  S Yahara ,  T Nohara ,  M Shibata
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
PMID: 2828297 DOI: 10.7164/antibiotics.40.1698
Abstract

A streptothricin-like Antibiotic, A-269A (referred to as A-269A hereafter) was isolated from the culture broth of Streptomyces sp., strain No. A-269. In this paper, the characterization of the producer, and the production, isolation, physico-chemical properties and biological properties of A-269A are reported. The structure of the Antibiotic was also examined by 1H NMR, 13C NMR and fast atom bombardment mass spectra studies. From the spectroscopic data, A-269A was assumed to be a mixture of Antibiotic LL-BL 136 and an isomeric compound in which the carbamoyl group is substituted on C-12' hydroxyl instead of C-10 hydroxyl.

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