Geranylpyrrol A and Piericidin F from Streptomyces sp. CHQ-64 ΔrdmF

  • J Nat Prod. 2017 May 26;80(5):1684-1687. doi: 10.1021/acs.jnatprod.7b00016.
Xiaoning Han  1 ,  Zengzhi Liu  1 ,  Zhenzhen Zhang  1 ,  Xiaomin Zhang  1 ,  Tianjiao Zhu  1 ,  Qianqun Gu  1 ,  Wenli Li  1 ,  Qian Che  1 ,  Dehai Li  1  2
Affiliations
  • 1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
  • 2. Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology , Qingdao 266237, People's Republic of China.
PMID: 28418245 DOI: 10.1021/acs.jnatprod.7b00016
Abstract

Two new compounds, geranylpyrrol A (1) and piericidin F (2), were isolated from a reedsmycins nonproducing mutant strain of Streptomyces sp. CHQ-64. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, NOESY, and ECD analyses. Geranylpyrrol A (1) is an unusual naturally occurring 2,3,4-trisubstituted pyrrole, and piericidin F (2) showed cytotoxicity against HeLa, NB4, A549, and H1975 cell lines with IC50 values of 0.003, 0.037, 0.56, and 0.49 μM, respectively.