Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis

  • J Nat Prod. 2017 Dec 22;80(12):3159-3166. doi: 10.1021/acs.jnatprod.7b00412.
Yao-Yue Fan  1 ,  Jin-Biao Xu  1 ,  Hong-Chun Liu  1 ,  Li-She Gan  2 ,  Jian Ding  1 ,  Jian-Min Yue  1
Affiliations
  • 1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
  • 2. Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University , Hangzhou 310058, People's Republic of China.
PMID: 29182349 DOI: 10.1021/acs.jnatprod.7b00412
Abstract

Ten new cephalotane-type Diterpenoids, cephanolides A-J (1-10), and two known analogues were isolated and characterized from Cephalotaxus sinensis. Compounds 1-3 represent the first examples of A-ring-contracted cephalotane-type dinorditerpenoids, and compound 4 is an A-ring-contracted norditerpenoid. The biosynthetic pathways for compounds 1-4 are postulated with the coexisting cephalotane-type troponoids as the precursors. Compounds 11 and 12 showed significant cytotoxicities against a panel of tumor cell lines (A549, KB, HL-60, and HT-29) with IC50 values ranging from 0.464 to 6.093 μM.