Ophiobolins from the Mangrove Fungus Aspergillus ustus

  • J Nat Prod. 2018 Jan 26;81(1):2-9. doi: 10.1021/acs.jnatprod.7b00335.
Tonghan Zhu  1 ,  Zhenyu Lu  1 ,  Jie Fan  1 ,  Liping Wang  1  2 ,  Guoliang Zhu  1 ,  Yi Wang  1 ,  Xia Li  3 ,  Kui Hong  4 ,  Pawinee Piyachaturawat  5 ,  Arthit Chairoungdua  5 ,  Weiming Zhu  1
Affiliations
  • 1. Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, China.
  • 2. Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002, China.
  • 3. School of Ocean, Shandong University , Weihai 264209, China.
  • 4. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education of China, School of Pharmaceutical Sciences, Wuhan University , Wuhan 430071, China.
  • 5. Department of Physiology, Faculty of Science, Mahidol University , Bangkok 10400, Thailand.
PMID: 29286660 DOI: 10.1021/acs.jnatprod.7b00335
Abstract

Seven new ophiobolins (1-5, 12, and 14) along with the 11 known analogues (6-11, 13, 15-18) were isolated from the ethyl acetate extracts of the liquid and solid cultures of the mangrove fungus Aspergillus ustus 094102. The structures including the absolute configurations of the seven new compounds were elucidated by spectroscopic analysis, chemical methods, and quantum ECD calculations. Compounds 4-8 and 11-15 showed cytotoxicities against the G3K, MCF-7, MD-MBA-231, MCF/Adr, A549, and HL-60 human Cancer cell lines with the IC50 values ranging from 0.6 to 9.5 μM.