New dihydrophenanthrenes from Dendrobium infundibulum

  • Nat Prod Res. 2019 Feb;33(3):420-426. doi: 10.1080/14786419.2018.1455050.
Salinee Na Ranong  1 ,  Kittisak Likhitwitayawuid  1 ,  Wanwimon Mekboonsonglarp  2 ,  Boonchoo Sritularak  1  3
Affiliations
  • 1. a Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany, Chulalongkorn University , Bangkok , Thailand.
  • 2. b Scientific and Technological Research Equipment Centre Chulalongkorn University , Bangkok , Thailand.
  • 3. c Natural Products for Ageing and Chronic Diseases Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University , Bangkok , Thailand.
PMID: 29569485 DOI: 10.1080/14786419.2018.1455050
Abstract

Two new dihydrophenanthrenes, dendroinfundin A (1) and dendroinfundin B (2) were isolated from the whole plant of Dendrobium infundibulum, together with 7 known compounds (3-9). The structures of the new compounds (1 and 2) were established on the basis of their spectroscopic data. All of the isolates were evaluated for their α-glucosidase and pancreatic Lipase inhibitory activities. Batatasin III (5) and dendrosinen B (9) showed strong α-glucosidase inhibitory activity. Dendrosinen B (9) also exhibited appreciable pancreatic Lipase inhibitory effect.

Keywords
dihydrophenanthrene; ochidaceae; pancreatic lipase; α-glucosidase.
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