New Acetophenone Derivatives from Acronychia oligophlebia and Their Anti-inflammatory and Antioxidant Activities

  • Chem Biodivers. 2018 May;15(5):e18000080. doi: 10.1002/cbdv.201800080.
Neng-Hua Chen  1  2 ,  Wen Li  3 ,  Yuan-Lin Zhong  1  2 ,  Qian-Wen Niu  1  2 ,  Ying-Ying Li  1  2 ,  Yu-Bo Zhang  1  2 ,  Man-Mei Li  1  2 ,  Yao-Lan Li  1  2 ,  Guo-Cai Wang  1  2
Affiliations
  • 1. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.
  • 2. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, P. R. China.
  • 3. Guangdong Saskatchewan Oilseed Joint Laboratory, Guangdong Engineering Technology Research Center for Oils and Fats Biorefinery, Department of Food Science and Engineering, Jinan University, Guangzhou, 510632, China.
PMID: 29624846 DOI: 10.1002/cbdv.201800080
Abstract

Seven new acetophenone derivatives (acroliones A - G, 1 - 7) and three known ones (8 - 10) were isolated from the leaves of Acronychia oligophlebia. Their structures were elucidated based on extensive spectroscopic analyses (IR, UV, HR-ESI-MS, 1D- and 2D-NMR), X-ray diffraction and comparison with literature data. The anti-inflammatory and antioxidant activities of all isolates were evaluated.

Keywords
Acronychia oligophlebia; acetophenone derivatives; anti-inflammatory activity; antioxidant activity; structural elucidation.
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