Theranostic micelles combined with multiple strategies to effectively overcome multidrug resistance

  • Nanomedicine (Lond). 2018 Jul;13(13):1517-1533. doi: 10.2217/nnm-2017-0393.
Dan Zhao  1 ,  Qing Chen  1 ,  Hua Song  1 ,  Shuting Luo  1 ,  Pingyun Ge  1 ,  Yingjun Wang  1 ,  Jinyuan Ma  1 ,  Zhi Li  1 ,  Xuemin Gao  1 ,  Xuemei Zhao  1 ,  Xiayiding Subinuer  1 ,  Huayu Yang  1 ,  Xiaojuan Jiang  1 ,  Yanxin Chen  1 ,  Xuan Zhu  1
Affiliations
  • 1. Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, PR China.
PMID: 30028224 DOI: 10.2217/nnm-2017-0393
Abstract

Aim: To develop precise targeting and versatile Fe3O4@SiO2-P123/PTX-ZnPc nanoparticles (FSP-PTX-ZnPc NPs) to reverse paclitaxel (PTX)-induced multidrug resistance in breast Cancer.

Materials & methods: PTX and zinc (II) phthalocyanine (ZnPc) co-loaded FSP-PTX-ZnPc NPs were designed. The resulting multifunctional NPs were evaluated systematically in vitro and in vivo, and the mechanism of drug-resistance reversal was investigated.

Results: The NPs enhanced drug uptake in MCF-7/PDR cells by increasing drug solubility and impairing P-glycoprotein efflux. Additionally, magnetic targeting and enhanced permeation and retention (EPR) effect enhanced drug accumulation in tumor, facilitating the chemotherapeutic and photodynamic therapy effects. Moreover, FSP-PTX-ZnPc NPs could penetrate the blood-brain barrier, a desirable trait for brain disease therapy.

Conclusion: The multifunctional FSP-PTX-ZnPc NPs are an effective tool for overcoming drug resistance in breast Cancer.

Keywords
breast cancer; drug resistance; magnetic targeting; nanoparticles; paclitaxel; photodynamic therapy; zinc(II) phthalocyanine.
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