Matrix Metalloproteinase-8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri-Implant Diseases

  • Int J Dent. 2018 Sep 16:2018:7891323. doi: 10.1155/2018/7891323.
Ahmed Al-Majid  1 ,  Saeed Alassiri  2 ,  Nilminie Rathnayake  3 ,  Taina Tervahartiala  2 ,  Dirk-Rolf Gieselmann  4 ,  Timo Sorsa  2  3
Affiliations
  • 1. Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zurich, Zurich, Switzerland.
  • 2. Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • 3. Karolinska Institutet, Department of Dental Medicine, Division of Periodontology, Stockholm, Sweden.
  • 4. Institute of Molecular Diagnostics, Dentognostics GmbH, Solingen and Jena, Germany.
PMID: 30305812 DOI: 10.1155/2018/7891323
Abstract

Levels of and especially the degree of activation of matrix metalloproteinase (MMP-8) in oral fluids (i.e., saliva, mouth rinse, gingival crevicular fluid (GCF) and peri-implantitis sulcular fluid (PISF)) increase to pathologically elevated levels in the periodontal and peri-implant diseases. This study aimed at collecting and collating data from previously published studies and determining whether active MMP-8 (aMMP-8) could serve as a biomarker for the diagnosis and prevention of periodontal and peri-implant diseases. The literature search identified a total of 284 articles. Out of 284 articles, 61 articles were found to be relevant. Data obtained from the selected studies were combined, and it indicated that aMMP-8 in oral fluids exerts the strong potential to serve as a useful adjunctive diagnostic and preventive biotechnological tool in periodontal and peri-implant diseases. aMMP-8 can be used alone or in combination with Other proinflammatory and/or microbiological biomarkers.