FGF19 subfamily members: FGF19 and FGF21

  • J Physiol Biochem. 2019 Jun;75(2):229-240. doi: 10.1007/s13105-019-00675-7.
Katarzyna Dolegowska  1 ,  Malgorzata Marchelek-Mysliwiec  1 ,  Monika Nowosiad-Magda  2 ,  Michal Slawinski  3 ,  Barbara Dolegowska  4  5
Affiliations
  • 1. Clinical Department of Nephrology, Transplantology, and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
  • 2. Department of Immunology Diagnostics, Pomeranian Medical University, Szczecin, Poland.
  • 3. Department of Laboratory Diagnostics, Independent Public Clinical Hospital No. 2, Pomeranian Medical University, Szczecin, Poland.
  • 4. Department of Laboratory Diagnostics, Independent Public Clinical Hospital No. 2, Pomeranian Medical University, Szczecin, Poland. [email protected].
  • 5. Department of Laboratory Medicine, Pomeranian Medical University, Szczecin, Poland. [email protected].
PMID: 30927227 DOI: 10.1007/s13105-019-00675-7
Abstract

Fibroblast growth factors (FGF) constitute a large family of proteins with pleiotropic effects on development, organogenesis, and metabolism. The FGF19 subclass includes growth factors circulating with the blood referred to as endocrine FGF. Representatives of the FGF19 subclass, including FGF19, FGF21, and FGF23, act via FGFR receptors. The proteins of FGF19 subfamily influence the enterohepatic circulation of bile, participate in glucose and lipid metabolism regulation, and maintenance of phosphorus and vitamin D3 homeostasis. FGF19 and FGF21 are activated under different physiological and pathological conditions.

Keywords
Bile acids; FGF19; FGF21; Klotho; Metabolism regulation.