Practical Method for Preparation of ( S)-2-Amino-5,5,5-trifluoropentanoic Acid via Dynamic Kinetic Resolution

  • ACS Omega. 2019 Jul 9;4(7):11844-11851. doi: 10.1021/acsomega.9b01537.
Haibo Mei  1 ,  Jianlin Han  1 ,  Ryosuke Takeda  2  3 ,  Tsubasa Sakamoto  2 ,  Toshio Miwa  2 ,  Yutaka Minamitsuji  2 ,  Hiroki Moriwaki  2 ,  Hidenori Abe  2 ,  Vadim A Soloshonok  3  4
Affiliations
  • 1. College of Chemical Engineering Nanjing Forestry University, Nanjing 210037, China.
  • 2. Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.
  • 3. Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, San Sebastián 20018, Spain.
  • 4. IKERBASQUE-Basque Foundation for Science, María Díaz de Haro 3, Plaza Bizkaia, Bilbao 48013, Spain.
PMID: 31460294 DOI: 10.1021/acsomega.9b01537
Abstract

This work reports an operationally convenient ∼20 g scale synthesis of (S)-2-amino-5,5,5-trifluoropentanoic acid and its Fmoc-derivative via dynamic kinetic resolution of the corresponding racemate.

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