Two new biflavanoids from Selaginella trichoclada Alsto

  • Nat Prod Res. 2021 Oct;35(20):3410-3416. doi: 10.1080/14786419.2019.1700506.
Yang Xie  1 ,  Ping-Sheng Xu  1 ,  Kang-Ping Xu  2 ,  Zhen-Xing Zou  2 ,  Gan Zhou  1 ,  Dai Li  1 ,  Dan Li  1 ,  Xiao-Min Li  1 ,  Jing Li  1 ,  Gui-Shan Tan  1  2
Affiliations
  • 1. Xiangya Hospital of Central South University, Changsha, PR China.
  • 2. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China.
PMID: 31841035 DOI: 10.1080/14786419.2019.1700506
Abstract

Two new robustaflavones, (±)-trichocladabiflavone A (1) and uncinatabiflavone E (2), along with seven known biflavanoids (3-9) were isolated from the 70% EtOH extract of Selaginella trichoclada. Their structures and absolute configurations were established by extensive spectroscopic and circular dichroism (CD) analyses. Compound 1 was resoluted into optically pure enantiomers (+)-1 and (-)-1 by chiral-phase HPLC. Moreover, compounds 1 and 2 exhibited moderate cytotoxicity against A549 and HepG2 human Cancer cell lines.

Keywords
Selaginella trichoclada; cytotoxicity; robustaflavone.
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