Picraquanines A－C, three new phenolic derivatives from the stems of Picrasma quassioides

  • Nat Prod Res. 2021 Nov;35(21):3687-3693. doi: 10.1080/14786419.2020.1727475.
Rui Xu  1 ,  Dongdong Zhang  1 ,  Fangfang Shu  2 ,  Zehai Long  1 ,  Yiming Li  1 ,  Zhengtao Wang  2 ,  Li Yang  2  3 ,  Rui Wang  1
Affiliations
  • 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
  • 2. The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
  • 3. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
PMID: 32056448 DOI: 10.1080/14786419.2020.1727475
Abstract

Three new phenolic derivatives, picraquanines A-C (1-3), along with 6 known ones 4-9 were obtained from the stems of Picrasma quassioides (D. Don) Benn. The new structures were determined by extensive spectroscopic data analysis, including IR, HRESIMS, 1H-NMR, 13C-NMR, HSQC, HMBC, 1H-1H COSY experiments. The absolute configuration of 1 was determined by comparison of its experimental and calculated ECD spectra. Furthermore, all the compounds were tested for their nitric oxide (NO) inhibitory effects against LPS-stimulated RAW 264.7 cells, however, none of them exhibited inhibitory effects (IC50 >100 μM).[Figure: see text].

Keywords
NO inhibitory activity; Picraquanines A－C; Picrasma quassioides; structure determination.
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