Pubescenosides Q-R, two new phenolic glycosides from Ilex pubescens

  • J Asian Nat Prod Res. 2021 Apr;23(4):363-370. doi: 10.1080/10286020.2020.1737858.
Fang Chen  1 ,  Shi-Yun Huang  1 ,  Shu-Qing Xiang  1 ,  Xiao-Xu Qiao  1 ,  Guo-Chao Liao  1 ,  Zhong-Qiu Liu  1  2 ,  Hua Zhou  2 ,  Peng Wu  1
Affiliations
  • 1. Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China.
  • 2. State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau 999078, China.
PMID: 32162545 DOI: 10.1080/10286020.2020.1737858
Abstract

Two new phenolic glycosides (1-2), along with six existing compounds (3-8), were isolated from the ethanolic extract of Ilex pubescens roots, a traditional folk medicine. These structures were determined using HR-ESI-MS, IR, UV, and NMR (including 1 D, 2 D-NMR). The anti-inflammatory activities of three phenolic glycosides (1-3) were evaluated in the human HepG2 cell lines. The results showed that compound 3 could induce P-gp and BCRP expression through the Nrf2-mediated pathway.[Formula: see text].

Keywords
Aquifoliaceae; Ilex pubescens; anti-inflammation; phenolic glycosides.
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