New butyrolactone derivatives from the endophytic Fungus Talaromyces sp. CPCC 400783 of Reynoutria japonica Houtt

  • J Antibiot (Tokyo). 2021 Apr;74(4):225-232. doi: 10.1038/s41429-020-00388-w.
Ran Zhang  #  1 ,  Wenni He  #  1 ,  Yujia Wang  2 ,  JianYuan Zhao  2 ,  Rui Zhou  2 ,  Li Li  3 ,  Yize He  4 ,  Shan Cen  2 ,  Liyan Yu  5
Affiliations
  • 1. China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
  • 2. Immunology Division, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
  • 3. Department of Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
  • 4. College of Biochemical Engineering, Beijing Union University, Beijing, 100101, China.
  • 5. China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. [email protected].
  • # Contributed equally.
PMID: 33361780 DOI: 10.1038/s41429-020-00388-w
Abstract

Six new butyrolactone derivatives (1, 2a/2b, 3a/3b and 4), together with another two known derivatives (5 and 6) were isolated from the endophytic fungus Talaromyces sp. CPCC 400783. Their structures were established by a combination of spectroscopic analysis, including NMR and HRESIMS. The absolute configurations were elucidated by ECD experiments. Subsequently, compound 1, 3b, 4 and 5 exhibited good inhibitory effect against influenza A/WSN/33 (H1N1) virus with IC50 values of 21.93 ± 1.51, 21.54 ± 3.75, 18.36 ± 2.15 and 23.80 ± 3.05 μM respectively.

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