Effect of 6,9,12,15-Hexadecatetraenoic Acid (C16:4n-1)-Ethyl Ester on Lipid Content and Fatty Acid Composition in the Blood and Organs of Mice

  • J Oleo Sci. 2021 May 1;70(5):703-712. doi: 10.5650/jos.ess21025.
Ryota Hosomi  1 ,  Toshifumi Tanizaki  1  2 ,  Shintaro Ikawa  1 ,  Tadahiro Tsushima  2 ,  Yoshihisa Misawa  2 ,  Naomichi Baba  2 ,  Munehiro Yoshida  1 ,  Kenji Fukunaga  1
Affiliations
  • 1. Department of Life Science and Biotechnology, Kansai University.
  • 2. Bizen Chemical Co., Ltd.
PMID: 33840668 DOI: 10.5650/jos.ess21025
Abstract

The effects of 6,9,12,15-hexadecatetraenoic acid (C16:4n-1, HDTA), an n-1 polyunsaturated fatty acid (FA), on plasma and liver lipid content and distribution in blood and tissues were investigated. Mice were fed experimental diets containing 10% HDTA or eicosapentaenoic acid in ethyl ester form based on corn oil for four weeks. Dietary HDTA intake lowered plasma triacylglycerol content without affecting plasma total Cholesterol content. HDTA barely accumulated in the epididymal white adipose tissue (eWAT), while C18:4n-1, an HDTA metabolite, was detected in small amounts (< 1% of total FAs) in the plasma, liver, and eWAT.

Keywords
n-1 polyunsaturated fatty acid; 6,9,12,15-hexadecatetraenoic acid; eicosapentaenoic acid; fish oil; mice.
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