Research-Relevant Clinical Pathology Resources: Emphasis on Mice, Rats, Rabbits, Dogs, Minipigs, and Non-Human Primates

  • ILAR J. 2021 Dec 31;62(1-2):203-222. doi: 10.1093/ilar/ilab028.
Liza Bau-Gaudreault  1 ,  Tara Arndt  2 ,  Anne Provencher  3 ,  Cory F Brayton  4
Affiliations
  • 1. Clinical Laboratories, Charles River Laboratories - ULC, Senneville, Quebec, Canada.
  • 2. Labcorp Drug Development, Madison, Wisconsin, United States.
  • 3. Clinical Laboratories, Charles River Laboratories - ULC, Sherbrooke, Quebec, Canada.
  • 4. Molecular and Comparative Pathobiology, John Hopkins University, School of Medicine, Baltimore, Maryland, USA.
PMID: 34877602 DOI: 10.1093/ilar/ilab028
Abstract

Clinical pathology testing for investigative or biomedical research and for preclinical toxicity and safety assessment in laboratory Animals is a distinct specialty requiring an understanding of species specific and other influential variables on results and interpretation. This review of clinical pathology principles and testing recommendations in laboratory animal species aims to provide a useful resource for researchers, veterinary specialists, toxicologists, and clinical or anatomic pathologists.

Keywords
Clinical chemistry; clinical pathology; coagulation; cytology; hematology; laboratory animal; safety assessment; toxicology.