Six new secoiridoid glycosides from the stem barks of Syringa Reticulata (Bl.) Hara

  • Fitoterapia. 2022 Mar;157:105128. doi: 10.1016/j.fitote.2022.105128.
Yan Liu  1 ,  Hui-Chen Zhu  1 ,  Shuang Guo  1 ,  Pei Liu  1 ,  Hai-Dan Zou  1 ,  Anam Naseem  1 ,  Juan Pan  1 ,  Wei Guan  1 ,  Hai-Xue Kuang  2 ,  Bing-You Yang  3
Affiliations
  • 1. Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.
  • 2. Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China. Electronic address: [email protected].
  • 3. Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China. Electronic address: [email protected].
PMID: 35041894 DOI: 10.1016/j.fitote.2022.105128
Abstract

Six new secoiridoids, syrretosides E-J (1-6) and four known secoiridoids (7-10), were isolated from the stem barks of Syringa reticulata. Their structures were established by the 1D and 2D NMR spectra, HR-ESI-MS, and comparison with the literature. The cytotoxicity of the isolated monomeric compounds against RAW264.7 cells was investigated by the CCK8 assay, and the results showed that the individual compounds were not cytotoxic to RAW264.7. The anti-inflammatory activity of these compounds was evaluated using the LPS-induced RAW264.7 inflammatory cell model and the results showed that compounds 3-7 and 9 showed varying degrees of anti-inflammatory activity.

Keywords
Chemical constituents; Cytotoxicity; Secoiridoids; Syringa reticulata.
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