The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis

  • Cell Res. 2022 Jul;32(7):687-690. doi: 10.1038/s41422-022-00642-w.
Renhong Yan  #  1  2 ,  Enjun Xie  #  3  4 ,  Yaning Li  #  5 ,  Jin Li  #  3  4 ,  Yuanyuan Zhang  1 ,  Ximin Chi  1 ,  Xueping Hu  6 ,  Lei Xu  7 ,  Tingjun Hou  6 ,  Brent R Stockwell  8 ,  Junxia Min  9 ,  Qiang Zhou  10 ,  Fudi Wang  11  12
Affiliations
  • 1. Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
  • 2. Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.
  • 3. The First Affiliated Hospital, The Fourth Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Cancer Center, State Key Laboratory of Experimental Hematology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
  • 4. The First Affiliated Hospital, The Second Affiliated Hospital, Basic Medical Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
  • 5. Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.
  • 6. Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
  • 7. Institute of Bioinformatics and Medical Engineering, Jiangsu University of Technology, Changzhou, Jiangsu, China.
  • 8. Department of Biological Sciences and Department of Chemistry, Columbia University, New York, NY, USA.
  • 9. The First Affiliated Hospital, The Fourth Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Cancer Center, State Key Laboratory of Experimental Hematology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. [email protected].
  • 10. Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China. [email protected].
  • 11. The First Affiliated Hospital, The Fourth Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Cancer Center, State Key Laboratory of Experimental Hematology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. [email protected].
  • 12. The First Affiliated Hospital, The Second Affiliated Hospital, Basic Medical Sciences, School of Public Health, Hengyang Medical School, University of South China, Hengyang, Hunan, China. [email protected].
  • # Contributed equally.
PMID: 35352032 DOI: 10.1038/s41422-022-00642-w