Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction

  • RSC Adv. 2018 Oct 10;8(60):34543-34551. doi: 10.1039/c8ra07576j.
Daria S Novikova  1 ,  Tatyana A Grigoreva  1 ,  Andrey A Zolotarev  2 ,  Alexander V Garabadzhiu  1 ,  Vyacheslav G Tribulovich  1
Affiliations
  • 1. Laboratory of Molecular Pharmacology, Saint Petersburg State Institute of Technology (Technical University) Moskovskii pr. 26 Saint Petersburg 190013 Russia [email protected].
  • 2. Department of Crystallography, Saint Petersburg State University per. Dekabristov 16 Saint Petersburg 199155 Russia.
PMID: 35548634 DOI: 10.1039/c8ra07576j
Abstract

A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C-H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.

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